Are you asking for a challenge?
When you equip one of these talismans, enemies gain a variety of new powers and bosses become substantially harder. This is intentionally a more difficult way to play Twilight Heroes and shouldn't be attempted unless you think things are just too easy.
That said, there are a variety of rewards for taking on these challenges, including a shot at your initials on this board... If you wear one of these talismans for an entire retcon and beat the clock.
"Too Hard" is activated by equipping one of the following talismans: